Which dental condition is associated with blue sclera and multiple bone fractures?

Which dental condition is associated with blue sclera and multiple bone fractures?

• A. Pernicious anemia
• B. Dentinogenesis imperfecta
• C. Hemolytic anemia
• D. Hypoplasia

Answer: (B)

The condition associated with blue sclera and multiple bone fractures is dentinogenesis imperfecta. This genetic disorder primarily affects the development of dentin, which is the hard tissue beneath the enamel of teeth. The genetic mutations that cause dentinogenesis imperfecta also affect the collagen synthesis in the bones, leading to a characteristic blue tint of the sclera—the white part of the eye—due to the underlying choroidal veins being visible. In individuals with dentinogenesis imperfecta, the compromised structural integrity of both dentin and bone can result in fragile bones, making them susceptible to frequent fractures. The appearance of blue sclera is a distinctive clinical feature that reflects the underlying collagen deficiency affecting multiple tissues, including bones. This combination of symptoms—dentin issues and skeletal fragility—strongly points to dentinogenesis imperfecta, distinguishing it from the other conditions listed.

The condition associated with blue sclera and multiple bone fractures is dentinogenesis imperfecta. This genetic disorder primarily affects the development of dentin, which is the hard tissue beneath the enamel of teeth. The genetic mutations that cause dentinogenesis imperfecta also affect the collagen synthesis in the bones, leading to a characteristic blue tint of the sclera—the white part of the eye—due to the underlying choroidal veins being visible.

In individuals with dentinogenesis imperfecta, the compromised structural integrity of both dentin and bone can result in fragile bones, making them susceptible to frequent fractures. The appearance of blue sclera is a distinctive clinical feature that reflects the underlying collagen deficiency affecting multiple tissues, including bones. This combination of symptoms—dentin issues and skeletal fragility—strongly points to dentinogenesis imperfecta, distinguishing it from the other conditions listed.